SynD - Synapse and neurite detection

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SynD is an automated image analysis routine to analyze dendrite and synapse characteristics in immuno-fluorescence images.

Purpose

The program analyses 2D immuno-fluorescence images (LSM or TIFF files) of neurons that were labeled with antibodies against a dendrite marker, synaptic vesicle protein and an additional protein of interest. SynD detects soma, neurites and synapses and reports dendrite morphology and branching, synapse size and number but also synaptic vesicle density and synaptic accumulation of proteins as a function of distance from the soma.

If you use this software please reference our article:

Automated Analysis of Neuronal Morphology, Synapse Number and Synaptic Recruitment. Schmitz SK, Hjorth JJJ, et al Journal of Neuroscience Methods 195 (2011) 185–193 http://dx.doi.org/10.1016/j.jneumeth.2010.12.011

License: CC-BY-NC-SA
http://creativecommons.org/licenses/by-nc-sa/3.0/

License

CC-BY-SA

Prerequirements

MATLAB 2009a or later, with imaging toolbox and statistics toolbox.

Ease of Use

Anyone can use it

Maturity

Intermediate

Operating system

Any

Downloads

This tool has been downloaded 192 times.

2 files

1 external files

1 external documentation item

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Topics

Neuroimaging

Keywords

neuronal morphology, image analysis, synaptopathies, dendrites, synapses, immuno-fluorescence,

Sections